Welcome to the Meinecke Lab


We just published that the ERAD pore formed by Hrd1 is the first ubiquitin-gated channel ever described.
Congrats Niels and Vedran, we are very proud of you.

Meinecke Lab

Prof. Dr. Michael Meinecke | CV

University Medical Center Göttignen
Department of Cellular Biochemistry
Humboldtallee 23
37073 Göttingen
Germany

Tel. Office: +49 (0)551 39 8189
Tel. Lab: +49 (0)551 39 8188

E-Mail: michael.meinecke[at]med.uni-goettingen.de

Present Group Members

PostDocs

Dr. Mariam Barbot | Mari did her PhD in our group, identifying Mic10 as a major regulator of inner mitochondrial membrane morphology. She now is a joined PostDoc with the Jakobs group and still interested in how Mic10 works on a molecular level.

Dr. Daryna Tarasenko | After doing her PhD with us Daryna now is a PostDoc in our group. She works towards a comprehensive understanding of how cristae junctions are formed in the mitochondrial inner membrane.

PhD students

Mausumi Ghosh | Mausumi joined our group in 2019. During her PhD thesis she will characterize protein translocation pores using high-resolution single-channel electropyhsiology.

Barbora Knotková | Barbora joined our lab most recently as a PhD student. She works towards a reconstitution and functional characterization of membrane contact sites

Indrani Mukherjee | In her PhD thesis Indrani is working on the details of MICOS dependent membrane remodeling.

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Fereshteh Sadeqi | Fereshteh is a PhD student in the lab. She is interested in the molecular details of protein-lipid interactions.

Staff

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Tanja Gall | Tanja is our technician.

Alumni

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Dr. Niels Denkert | Niels did his PhD thesis and a PostDoc our group. He is now on his way to become a patent laywer.

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Dr. Benjamin Kroppen | Ben did his PhD thesis in our group and worked on the cooperativity of proteins and lipids in endocytosis.

We are always interested in recruiting highly motivated and creative PostDocs and PhD students (also Bachelor and Master students are welcome) to study the fascinating molecular organization of biological membranes. Our lab takes an interdisciplinary approach to this topic, employing biophysical, biochemical and cell biological techniques. If you are interested in joining the group or have further questions do not hesitate to contact Michael Meinecke.

Research

Publications

2020

Vasic V., Denkert N., Schmidt C., Riedel D., Stein A., Meinecke M. (2020) Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins. Nature Cell Biology 22(3):274-281

Munzel L., Neumann P., Otto F.B., Krick R., Metje-Sprink J., Kroppen B., Karedla N., Enderlein J., Meinecke M., Ficner R., Thumm M. (2020) Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore. Autophagy https://doi.org/10.1080/15548627.2020.1766332

Steinem C., Meinecke M. (2020) ENTH domain-dependent membrane remodelling. Soft Matter https://doi.org/10.1039/C9SM02437A

Kondratiuk I., Jakhanwal S., Jin J., Sathyanarayanan U., Kroppen B., Pobbati A.V., Krisko A., Ashery U., Meinecke M., Jahn R., Fasshauer D., Milosevic I. (2020) PI(4,5)P2-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2. PNAS https://doi.org/10.1073/pnas.1908232117

Kroppen B., Teske N., Yambire K., Denkert N., Murkhejee I., Tarasenko D., Jaipuria G., Zweckstetter M., Milosevic I., Steinem C., Meinecke M. (2020) Cooperativity of membrane-protein and protein-protein interactions control membrane remodeling by epsin 1 and regulate clathrin-mediated endocytosis. BioRxiv doi: https://doi.org/10.1101/2020.01.27.920827

2019

Guan L., Denkert N., Eisa A., Lehmann M., Sjuts I., Weiberg A, Soll J., Meinecke M., Schwenkert S. (2019) JASSY - a Chloroplast Outer Membrane Protein Required for Jasmonate Biosynthesis. PNAS 116, 10568-10575

2017

Tarasenko D., Barbot M., Jans D.C., Kroppen B., Sadowski B., Heim G., Möbius W., Jakobs S., Meinecke M. (2017) The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology. Journal of Cell Biology 216, 889-899

Denkert N., Schendzielorz A.B., Barbot M., Versemann L., Richter F., Rehling P., Meinecke M. (2017) Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import. ELife pii: e28324. doi: 10.7554/eLife.28324

2016

Gleisner M., Kroppen B., Fricke C., Kliesch T.T., Janshoff A., Meinecke M.*, Steinem C.* (2016) Epsin N-terminal homology domain (ENTH) activity as a function of membrane tension. Journal of Biological Chemistry 291, 19953-19961 (*corresponding authors)

Barbot M., Meinecke M. (2016) Reconstitutions of mitochondrial inner membrane remodeling. Journal of Structural Biology 196, 20-28

2015

Barbot M, Jans D, Schulz C, Denkert N, Kroppen B, Hoppert M, Jakobs S, Meinecke M. (2015) Mic10 oligomerizes to bend mitochondrial inner membranes at cristae junctions. Cell Metabolism 5, 756-763

Montilla-Martinez M, Beck S, Meinecke M, Schliebs W, Wagner R, Erdmann R. (2015) Distinct pores for peroxisomal import of PTS1 and PTS2 proteins. Cell Reports 13, 2126-2134

Meinecke M*, Bartsch P, Wagner R. (2015) Peroxisomal Protein Import Pores. BBA Molecular Cell Research 1863(5), 821-827 (*corresponding author)

2014

Gleisner M, Mey I, Barbot M, Dreker C, Meinecke M, Steinem C. (2014) Driving a Planar Model System into the 3rd Dimension: Generation and Control of Curved Pore-Spanning Membrane Arrays. Soft Matter 10, 6228-6236

2013

Meinecke M*, Boucrot E, Camdere G, Hon WC, Mittal R, McMahon HT.* (2013) Cooperative recruitment of Dynamin and BAR domain-containing proteins leads to GTP-dependent membrane scission. Journal of Biological Chemistry 288, 6651-6661 (*corresponding authors)

Santos AJM, Meinecke M, Fessler MB, Holden DW, Boucrot E. (2013), Preferential targeting of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase. Journal of Cell Science 126, 2990-2996

2012

Reinhold R, Krüger V, Meinecke M, Schulz C, Schmidt B, Guiard B, Wiedemann N, van der Laan M, Wagner R, Rehling P. (2012) The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. Molecular and Cellular Biology 32, 5009-5021

Krüger V, Deckers M, Hildenbeutel M, van der Laan M, Hellmers M, Dreker C, Preuss M, Herrmann JM, Rehling P, Wagner R, Meinecke M. (2012) The mitochondrial Oxa1 insertase forms a membrane pore in lipid bilayers. Journal of Biological Chemistry 287, 33314-33326

Culham DE, Meinecke M, Wood JM. (2012) Impacts of the osmolality and the luminal ionic strength on osmosensory transporter ProP in proteoliposomes. Journal of Biological Chemistry 287, 27813-27822

Rassow J, Meinecke M. (2012) Helicobacter pylori VacA: A new perspective on an invasive chloride channel. Microbes and Infection 14, 1026-1033

2010

Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, Erdmann R. (2010) The Peroxisomal Importomer Constitutes a Large and Highly Dynamic Pore. Nature Cell Biology 12, 273 – 277

Henne WH*, Boucrot E*, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT. (2010) FCHo proteins are nucleators of clathrin-mediated endocytosis. Science 328, 1281-1284 (*authors contributed equally to this work)

Domańska G*, Motz C*, Meinecke M*, Harsman A, Papatheodorou P, Reljic B, Dian-Lothrop EA, Galmiche A, Kepp O, Becker L, Günnewig K, Wagner R, Rassow J. (2010) Helicobacter pylori VacA Toxin/Subunit p34: Mitochondrial Targeting of a Proapoptotic Anion Channel. PLoS Pathogens 6(4): e1000878. Doi:10.1371/ppat.1000878 (*authors contributed equally to this work)

2009

Kozjak-Pavlovic V*, Dian EA.*, Meinecke M*, Kepp O*, Ross K, Rajalingam K, Harsman A, Hauf E, Brinkmann V, Herrmann I, Günther D, Hurwitz R, Rassow J, Wagner R, Rudel T. (2009) Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis. PLoS Pathogens 5(10): e1000629. doi:10.1371/journal.ppat.1000629 (*authors contributed equally to this work)

2008

Kutik S, Stojanovski D, Becker T, Stoud DA, Becker L, Meinecke M, Krüger V, Prinz C, Guiard B, Wagner R, Meisinger C, Pfanner N, Wiedemann N. (2008) The Mitochondrial β-Signal and Protein Sorting. Cell 135, 1159-1160

Kutik S, Stojanovski D, Becker L, Becker T, Meinecke M, Krüger V, Prinz C, Meisinger C, Guiard B, Wagner R, Pfanner N, Wiedemann N. (2008) Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell 132, 1011-1024

2007

van der Laan M, Meinecke M, Dudek J, Hutu DP, Lind M, Perschil I, Guiard B, Wagner R, Pfanner N, Rehling P. (2007) Motor-free mitochondrial presequence translocase drives membrane integration of preproteins, Nature Cell Biology 9, 1155-1159

2006

Meinecke M, Wagner R, Kovermann P, Guiard B, Mick DU, Hutu DP, Voos W, Truscott K, Chacinska A, Pfanner N, Rehling P. (2006) Tim50 Maintains the Permeability Barrier of the Mitochondrial Inner Membrane. Science 312, 1523-1526

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Financial support